Metal Ion Released from Old Prostheses May Affect Oral Lesions:A Pilot Study
주혜민, 김지수, 안용우, 옥수민, 정성희,
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주혜민 ( Ju Hye-Min ) - Pusan National University Dental Hospital Department of Oral Medicine
김지수 ( Kim Ji-Su ) - Pusan National University School of Dentistry Department of Oral Medicine
안용우 ( Ahn Yong-Woo ) - Pusan National University School of Dentistry Department of Oral Medicine
옥수민 ( Ok Soo-Min ) - Pusan National University School of Dentistry Department of Oral Medicine
정성희 ( Jeong Sung-Hee ) - Pusan National University School of Dentistry Department of Oral Medicine
Abstract
Purpose: To investigate the correlation between the amount of salivary metal ions released from fixed prostheses and the period of restoration insertion, and to evaluate the correlation between the type and amount of metal ions in saliva and oral lesions (OL).
Methods: Based on the oldest prosthesis, we divided patients into two groups: more than 5 years (n=19) and less than 5 years (n=10). Patients were also divided into two groups by another criteria: the one with the presence (n=15), and the one with absence (n=14) of OL, and the amounts of metal ions were examined. Metal ions?gold (Au), copper, cobalt (Co), chromium (Cr), nickel, zinc, aluminum, palladium (Pd), tin, and platinum (Pt)?were measured using laser ablation microprobe inductively coupled plasma mass spectrometry.
Results: Significantly higher quantities of Co, Pt, and Pd ions were released in patients with fixed prosthesis of more than 5 years (p<0.05). Measurement of the average amount of salivary metal ions was performed on patients with and without OL - Significantly higher amounts of Cr, Pd and Au ions were released in patients with OL (p<0.05).
Conclusions: Old prostheses (≥5 years) released metal ions, and among them were Co, Pt and Pd ions more than others. Patients with OL showed significantly higher levels of ion release, especially Cr, Pd and Au. There was a positive correlation between the amount of a certain kind of released metal ions, especially Pd, and the development of OL. Salivary Pd ion released from old prostheses could affect the pathogenesis of OL; therefore, long-term follow-up is important.
키워드
Metals; Old prosthesis; Oral lesion; Saliva
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